How the Memmert Climate Chamber Optimizes the T-SPOT.TB Test at Revvity
Reliable diagnostics for latent tuberculosis depend on precisely controlled conditions. Accurate temperature control, stable CO₂ levels, and defined humidity are not optional—they are essential for generating reproducible results.
At its Oxford site, Revvity relies on the Memmert HPPCeco climate chamber specifically tailored to the requirements of the T-SPOT.TB test—while also significantly improving day-to-day laboratory efficiency.
Revvity is a global leader in life sciences, reproductive health, and immunodiagnostics. At its Oxford facility, the team plays a key role in performing the T-SPOT.TB test, a well-established method for detecting latent tuberculosis.
The importance of this diagnostic is substantial:
Around one quarter of the global population is estimated to carry latent tuberculosis, and in 2024 alone, more than 1.2 million people died from active TB.
This highlights the impact of every single test result - providing clarity and guidance for patient treatment decisions.
The T-SPOT.TB workflow requires incubation of patient cells under tightly controlled conditions:
These requirements go beyond standard applications. In addition, the transition between process steps—especially from day 1 to day 2—is critical for maintaining result quality.
Previously, this workflow required additional staffing effort. Laboratory personnel needed to be on-site during weekends to manage and continue the process.
With the integration of the Memmert HPPCeco climate chamber, Revvity was able to eliminate this bottleneck entirely:
The result is a continuous, stable process with significantly improved planning reliability.
A key advantage of the Memmert HPPCeco climate chamber is its ability to integrate seamlessly into existing laboratory processes.
The system precisely controls all critical parameters simultaneously:
During incubation, conditions are maintained with high accuracy. Afterwards, the system automatically and gradually adjusts parameters down to cooling conditions—without manual intervention.
This automated process ensures:
From the outset, Revvity defined clear and specific requirements—well beyond typical standard applications.
In close collaboration, a solution was developed that is precisely aligned with the T-SPOT.TB workflow. This approach is particularly important in regulated laboratory environments:
Technology must not only perform—it must integrate into validated, standardized, and accredited processes.
In addition to technical performance, the HPPCeco stands out in everyday use:
This reduces training effort while increasing operational safety and confidence.
The Oxford laboratory operates under UKAS accreditation and follows strict quality standards.
The Memmert solution supports these requirements through:
This directly contributes to ensuring consistent and reproducible diagnostic results.
Automation of the T-SPOT.TB workflow goes beyond operational efficiency—it directly affects patient care:
stable and controlled test conditions
These factors form the foundation for reliable clinical decision-making.
The integration of the Memmert climate chamber at Revvity Oxford shows how complex diagnostic requirements can be translated into a reliable and efficient workflow.
Where diagnostics directly impact patient outcomes, process quality is critical. The implemented solution makes a measurable contribution—every day.
